Senior Scientist, Bioscience

Senior Scientist, Bioscience

Introduction to role

Are you ready to make a significant impact in the field of bioscience? AstraZeneca is seeking a Senior Scientist to join our Bioscience Metabolism group within the Early Cardiovascular, Renal and Metabolism department. This role demands a deep understanding of in vivo pharmacology in rodent models related to obesity, diabetes, dyslipidemia, and MASH. Your expertise in obesity and weight management, including appetite and energy regulation within the CNS, will be crucial. If you have experience with various drug modalities and ex vivo lab techniques such as tissue gene expression, ELISAs, and western blot analysis, we want you on our team! You'll be at the forefront of experimental work, designing, executing, and interpreting preclinical data. Present your findings at group meetings and scientific conferences and collaborate across departments to drive innovation.

Accountabilities

• Highly proficient in working with rodent models of obesity, diabetes, dyslipidemia, and MASH – hands-on expertise in animal handling, dosing (SC, ICV, IV, PO, and IM), and necropsy tissue collections.

• Preclinical rodent surgical expertise including ICV cannulation via stereotaxic technique, SC Alzet pump implantation, and telemetry expertise.

• Experience with rodent tissue histopathology processing (H+E, IHC).

• Independently execute ex vivo analysis of blood/tissue samples including qPCR gene expression, Western blots, and ELISAs.

• Strong teamwork skills and experience working in a cross-functional team.

• Take part in all experimental work, including the design, analysis, and interpretation of data from these experiments.

• Prepare and present scientific data to in vivo group and project team meetings.

• Work in a cross-functional project team with responsibility for making decisions and recommendations for program in vivo pharmacology plans.

• Maintain an understanding of the scientific basis of the eCVRM project pipeline to successfully execute experiments needed to meet project requirements.

• Participate in collaborations related to specific projects.

• Raise the scientific profile of CVRM externally through publishing data in peer-reviewed journals and by presenting at conferences.

• Contribute to CVRM animal model work and/or development including areas of obesity, dyslipidemia, CV.

• Act as in vivo bioscience lead for drug discovery projects in metabolism disease area.

• Propose and champion new targets and novel approaches for disease treatment.

• Execution of metabolism in vivo assays including GTTs, ITTs, and measurement food intake.

Essential Skills/Experience

Education:

• PhD and 3+ years of relevant experience (preferred), or MS and 10+ years of relevant experience or BS and 13+ years of relevant experience

• Degree in a biological science field

At AstraZeneca, we are dedicated to making a difference in patients' lives. Our dynamic environment thrives on change and innovation. We embrace challenges with resilience and courage, always pushing boundaries to deliver groundbreaking solutions. Our collaborative culture values diverse perspectives and encourages bold decisions that can transform patient outcomes. With countless learning opportunities and a commitment to continuous improvement, AstraZeneca is where your expertise can truly shine.

Ready to take the next step in your career? Apply now to join our team of dedicated experts!

The annual base pay (or hourly rate of compensation) for this position ranges from $108,473 to $162,710. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

27-Jun-2025

Closing Date

10-Jul-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.